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Translational Medicine / 转化医学Molecular Glues, Cancer Drug Design

Caroline Bhatt

PhD

🏢Dana-Farber Cancer Institute🌐USA

Research Associate Professor, Drug Discovery

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👥Biography 个人简介

Dr. Caroline Bhatt is a drug discovery scientist at Dana-Farber specializing in molecular glue degraders, a class of drugs that induce targeted protein degradation by stabilizing protein-protein interactions with E3 ligases. Her work investigates the structural basis of cereblon-based molecular glues including IMiD analogs used in myeloma and other hematologic malignancies, and identifies novel molecular glue interactions with alternative E3 ligases for cancer drug development.

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🧪Research Fields 研究领域

molecular glue degraders cancer
cereblon molecular glue mechanism
IMiD structural basis thalidomide analogs
molecular glue structure-activity
novel E3 ligase glue discovery

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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