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Translational Medicine / 转化医学Breast Cancer Endocrine Resistance, HER2 Crosstalk

Carlos Arteaga

MD

🏢UT Southwestern Harold C. Simmons Comprehensive Cancer Center🌐USA

Professor and Director

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👥Biography 个人简介

Carlos Arteaga is one of the foremost experts on endocrine therapy resistance mechanisms in breast cancer, with particular focus on HER2-ER crosstalk as a driver of treatment failure. His landmark studies demonstrated that HER2 signaling activates ER in a ligand-independent manner contributing to tamoxifen and aromatase inhibitor resistance. He has investigated PI3K pathway inhibitors combined with endocrine therapy for resistant disease. His research has directly shaped clinical trials and treatment guidelines for HR+/HER2+ breast cancer.

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🧪Research Fields 研究领域

endocrine resistance HER2
ER+ breast cancer
PIK3CA breast
tamoxifen resistance mechanisms
CDK4/6 combinations

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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