Carlo M. Croce
卡洛·克罗切
MD
Professor and Chair, Department of Cancer Biology and Genetics; Director, Human Cancer Genetics Program癌症生物学与遗传学系主任、教授；人类癌症遗传学项目主任
👥Biography 个人简介
Carlo M. Croce is one of the most cited biomedical scientists in history, renowned for discovering the chromosomal translocations linking BCL2 to follicular lymphoma and for co-discovering the role of microRNAs as oncogenes and tumor suppressors. His work has fundamentally reshaped understanding of cancer initiation and progression at the molecular level.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BCL2 Oncogene Discovery
Demonstrated that the t(14;18) chromosomal translocation juxtaposes BCL2 with immunoglobulin loci, driving follicular lymphoma by blocking apoptosis—founding the concept of apoptosis deregulation in cancer.
MicroRNA as Oncogenes and Tumor Suppressors
Co-discovered that miR-15 and miR-16 are deleted in CLL and that miR-21 is overexpressed in multiple cancers, establishing miRNA dysregulation as a universal cancer mechanism and spawning a field.
TCL1 Oncogene and Leukemia Models
Identified TCL1 as an oncogene activated by chromosomal translocation in T-cell leukemia and developed transgenic mouse models recapitulating human CLL, enabling preclinical drug discovery.
Representative Works 代表性著作
Frequent deletions of miR-15a and miR-16-1 in CLL
Proceedings of the National Academy of Sciences (2002)
Landmark paper showing miR-15a/16-1 deletion at 13q14 drives CLL by upregulating BCL2, establishing microRNAs as tumor suppressors.
MicroRNA gene expression deregulation in human B cell chronic lymphocytic leukemia
Cancer Research (2004)
First global miRNA expression profiling in human cancer, demonstrating miRNA signatures can classify tumors and predict prognosis.
Clustering and conservation patterns of human microRNAs
Proceedings of the National Academy of Sciences (2003)
Comprehensive genomic mapping of human miRNA loci revealing frequent location at cancer-associated chromosomal fragile sites.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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