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Translational Medicine / 转化医学Langerhans Cell Histiocytosis, BRAF

Carl Allen

MD PhD

🏢Texas Children's Hospital / Baylor🌐USA

Associate Professor

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Key Contributions

👥Biography 个人简介

Carl Allen at Texas Children's has made contributions to understanding Langerhans cell histiocytosis (LCH) — a myeloid neoplasm with dendritic cell characteristics, now understood to be driven by MAPK pathway activation (BRAF V600E in ~50%). His work establishing LCH as a clonal myeloid neoplasm rather than an inflammatory disease, and on BRAF inhibitor activity in LCH, has transformed understanding of this disease.

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🧪Research Fields 研究领域

Langerhans cell histiocytosis
BRAF V600E LCH
MAPK pathway LCH
histiocytosis biology treatment
vemurafenib LCH

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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