Carien L. Creutzberg
卡里恩·克鲁茨贝格
MD, PhD
Professor of Radiation Oncology; Head, Gynecologic Radiation Oncology放射肿瘤学教授；妇科放射肿瘤科主任
👥Biography 个人简介
Carien L. Creutzberg, MD, PhD is Professor of Radiation Oncology at Leiden University Medical Center and the principal architect of the PORTEC (Post Operative Radiation Therapy in Endometrial Carcinoma) trial series. Her landmark trials have defined modern adjuvant radiation standards for endometrial cancer and contributed foundational evidence for cervical and uterine cancer radiotherapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PORTEC Trial Series: Defining Adjuvant Radiation in Endometrial Cancer
Led PORTEC-1, -2, and -3 trials that sequentially refined adjuvant radiotherapy for endometrial cancer, establishing vaginal brachytherapy as the preferred treatment for intermediate-risk patients and combining chemoradiation for high-risk disease.
Molecular Classification Integration in Endometrial Cancer Radiotherapy
PORTEC-3 and subsequent analyses integrated molecular classification (TCGA-based) with radiation therapy decisions, pioneering molecularly-guided radiation oncology in gynecologic cancers.
Representative Works 代表性著作
Adjuvant Radiotherapy for Endometrial Carcinoma (PORTEC-1)
The Lancet (2000)
Established that adjuvant pelvic radiotherapy reduces locoregional recurrence but does not improve overall survival in early endometrial cancer, fundamentally changing adjuvant treatment practice.
Vaginal Brachytherapy versus Pelvic Radiation for Intermediate-Risk Endometrial Cancer (PORTEC-2)
The Lancet (2010)
Showed vaginal brachytherapy is non-inferior to pelvic radiation with fewer side effects, establishing it as the new standard for intermediate-risk endometrial cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 卡里恩·克鲁茨贝格 的研究动态
Follow Carien L. Creutzberg's research updates
留下邮箱，当我们发布与 Carien L. Creutzberg（Leiden University Medical Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment