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Translational Medicine / 转化医学ADC Payload Innovation

Patrick Burke

PhD

🏢Seagen (now Pfizer)🌐USA

Senior Director, ADC Technologies

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👥Biography 个人简介

Patrick Burke is an ADC technology leader who has advanced auristatin payload chemistry and site-specific conjugation approaches at Seagen. His work on MMAE and MMAF payloads has underpinned multiple approved ADCs including brentuximab vedotin and enfortumab vedotin. He has innovated in linker stability and controlled drug release mechanisms.

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🧪Research Fields 研究领域

Auristatin payloads
MMAE/MMAF chemistry
Site-specific conjugation
ADC stability
Linker technology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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