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Translational Medicine / 转化医学Cancer Splicing Modulators

Silvia Buonamici

PhD

🏢H3 Biomedicine (Eisai)🌐USA

Vice President and Head of Cancer Biology

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Key Contributions

👥Biography 个人简介

Silvia Buonamici led cancer biology at H3 Biomedicine and advanced splicing modulator drug development including H3B-8800 targeting the SF3B1 splicing factor mutation in myelodysplastic syndromes and chronic lymphocytic leukemia. Her work established the cancer splicing modulator field. She is a leader in spliceosome-targeted drug discovery.

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🧪Research Fields 研究领域

splicing modulators
SF3B1 inhibitors
H3B-8800
cancer spliceosome
synthetic lethality

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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