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Translational Medicine / 转化医学HCC Immunotherapy, Nivolumab CheckMate 040

Bruno Sangro

MD, PhD

🏢Clinica Universidad de Navarra🌐Spain

Professor and Director, Liver Unit

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Key Contributions

👥Biography 个人简介

Bruno Sangro is a hepatologist and HCC oncologist who contributed to the landmark CheckMate 040 trial establishing nivolumab activity in sorafenib-refractory HCC. He has investigated combinations of locoregional therapies with systemic immunotherapy and the HIMALAYA trial of tremelimumab plus durvalumab in advanced HCC. His research integrates translational biomarker studies with clinical outcomes in HCC immunotherapy. He co-chairs the EASL HCC clinical practice guidelines and leads international HCC educational programs.

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🧪Research Fields 研究领域

HCC nivolumab CheckMate 040 early trials
HCC PD-1 immunotherapy efficacy
tremelimumab HIMALAYA HCC
HCC locoregional plus systemic combination
TACE plus systemic therapy HCC

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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