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Translational Medicine / 转化医学In Situ Vaccination and Intratumoral Therapy

Joshua Brody

MD

🏢Icahn School of Medicine at Mount Sinai🌐USA

Director, Lymphoma Immunotherapy Program

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Key Contributions

👥Biography 个人简介

Joshua Brody is a pioneer of in situ vaccination approaches that convert tumors into their own vaccines by injecting immunostimulatory agents directly into tumor sites. His clinical trials combining Flt3L, TLR agonists, and radiation have demonstrated systemic anti-tumor immunity from local treatment in lymphoma and breast cancer patients. His work has established the in situ vaccination paradigm as a viable immunotherapy strategy.

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🧪Research Fields 研究领域

In situ vaccination lymphoma
TLR9 agonist intratumoral
Flt3L dendritic cell mobilization
Intratumoral immunotherapy combinations
Abscopal effect induction

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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