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Translational Medicine / 转化医学Lung Cancer, KRAS G12C

Britta Eichler

MD

🏢Brigham and Women's Hospital🌐USA

Director, Oncology Drug Development

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👥Biography 个人简介

Dr. Britta Eichler specializes in early-phase oncology drug development with a focus on RAS pathway inhibitors. She is actively involved in clinical trials evaluating SOS1 inhibitors such as BI 1701963 in combination with KRAS G12C inhibitors. Her work explores rational combinations to prevent adaptive resistance through upstream RAS-GEF signaling that reactivates KRAS signaling under G12C inhibitor pressure.

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🧪Research Fields 研究领域

SOS1 inhibitors
KRAS G12C combination
pan-KRAS inhibitors
RAS pathway targeting
early-phase clinical trials

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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