Brian Marples
布莱恩·马普尔斯
PhD
Professor of Radiation Oncology放射肿瘤学教授
👥Biography 个人简介
Brian Marples is a distinguished radiation biologist at the University of Rochester whose research focuses on cellular responses to ionizing radiation, low-dose hypersensitivity, and adaptive radiotherapy strategies. His mechanistic insights have informed clinical fractionation approaches and treatment personalization.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Low-Dose Hypersensitivity
Pioneered research into the phenomenon of low-dose radiation hypersensitivity in tumor cells, revealing underlying DNA damage response mechanisms with implications for clinical fractionation design.
Adaptive Radiotherapy Biology
Investigated biological rationale for adaptive radiotherapy, examining how tumor microenvironment changes during treatment can guide real-time plan adaptation for improved therapeutic outcomes.
Representative Works 代表性著作
Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells
Radiation Research (2004)
Elucidated the cell cycle checkpoint basis of low-dose hypersensitivity, influencing understanding of fractionated radiotherapy responses.
Adaptive response and induced radioresistance
Mutation Research (2000)
Characterized adaptive radiation responses in mammalian cells, providing mechanistic insights relevant to radiotherapy optimization.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Brian Marples
University of Rochester Medical Center
Silvia C. Formenti
Weill Cornell Medicine / NewYork-Presbyterian Hospital
Paul M. Harari
University of Wisconsin School of Medicine and Public Health
Jeff Forman
Wayne State University / Karmanos Cancer Institute
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