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Translational Medicine / 转化医学Milestone, Imatinib CML

Brian Druker

MD

🏢Oregon Health and Science University (OHSU)🌐USA

Director, Knight Cancer Institute; JELD-WEN Chair in Leukemia Research

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👥Biography 个人简介

Brian Druker led the clinical development of imatinib (Gleevec/STI571) for chronic myeloid leukemia, translating the discovery of BCR-ABL into one of the most transformative cancer treatments ever created. The IRIS trial he led demonstrated that imatinib achieved complete cytogenetic remission in the vast majority of CML patients, fundamentally changing the disease from a fatal to a manageable chronic condition. He is widely regarded as a founding father of targeted cancer therapy.

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🧪Research Fields 研究领域

imatinib Gleevec CML
BCR-ABL inhibitor
targeted cancer therapy concept
CML molecular remission
tyrosine kinase inhibitor revolution

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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