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Translational Medicine / 转化医学Ewing Sarcoma, Bone and Soft Tissue

Brian Bhatt

MD

🏢Children's Hospital of Philadelphia🌐USA

Associate Professor of Pediatric Oncology

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👥Biography 个人简介

Brian Bhatt studies Ewing sarcoma, a highly aggressive soft tissue and bone tumor driven by EWSR1-FLI1 fusion oncoprotein. His research has explored how the EWSR1-FLI1 fusion reprograms gene expression and creates therapeutic vulnerabilities. He investigated PARP inhibitor sensitivity in Ewing sarcoma due to EWSR1-FLI1-induced DNA repair defects. His work also encompasses immunotherapy combinations for relapsed/refractory Ewing sarcoma in pediatric and young adult patients.

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🧪Research Fields 研究领域

Ewing sarcoma EWSR1-FLI1
PARP inhibitors Ewing
EWS immunotherapy
pediatric sarcoma
fusion transcription factors

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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