Brendan Manning

Brendan Manning at Harvard has made major contributions to understanding mTORC1 as a central integrator of nutrient, growth factor, and energy signals that regulate cell metabolism and growth in cancer. His work on the TSC1/TSC2 complex as a tumor suppressor and critical regulator of mTORC1 activity, and his research on the mechanisms by which mTORC1 senses amino acids and regulates metabolic gene expression, has been highly influential for understanding cancer metabolism and mTOR-targeted therapy.