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Translational Medicine / 转化医学CDK12 Synthetic Lethality
Karim Boutros
PhD
🏢Institut Gustave Roussy🌐France
Staff Scientist
30
h-index
0
Key Papers
0
Key Contributions
👥Biography 个人简介
Karim Boutros investigates CDK12 and related transcription kinases as therapeutic targets in ovarian and other gynecologic cancers. His work combines CRISPR screens and chemical biology to identify synthetic lethal partners of CDK12 loss. He translates mechanistic findings into combination strategies for clinical testing.
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🧪Research Fields 研究领域
CDK12
ovarian cancer
synthetic lethality
DNA damage
functional genomics
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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