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Translational Medicine / 转化医学AML Apoptosis, Venetoclax AML

Bhawana Bhatt

MD

🏢University of Michigan🌐USA

Assistant Professor of Hematology

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Key Papers
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Key Contributions

👥Biography 个人简介

Bhawana Bhatt studies mechanisms of venetoclax sensitivity and resistance in acute myeloid leukemia. Her research has defined how IDH mutations and other molecular features sensitize AML cells to BCL-2 inhibition. She has characterized resistance mechanisms including upregulation of MCL-1 and mitochondrial adaptations that blunt venetoclax efficacy. Her translational work aims to identify predictive biomarkers and rational combination partners to overcome venetoclax resistance in AML.

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🧪Research Fields 研究领域

AML venetoclax azacitidine
BCL-2 AML
mitophagy AML
resistance mechanisms
IDH mutations

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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