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Translational Medicine / 转化医学NOTCH Signaling, Breast Cancer, Solid Tumors

Bharat Bhatt

PhD

🏢University of Pennsylvania Abramson Cancer Center🌐USA

Professor of Cancer Cell Biology

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Key Contributions

👥Biography 个人简介

Bharat Bhatt investigates the roles of NOTCH signaling in breast cancer progression and cancer stem cell maintenance. His research has characterized how NOTCH pathway activation confers stem-like properties and treatment resistance in triple-negative breast cancer. He has examined NOTCH ligand-receptor interactions in the tumor microenvironment that promote tumor progression and immune evasion. His translational work has evaluated gamma-secretase inhibitor combinations and NOTCH ligand-blocking antibodies in preclinical breast cancer models.

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🧪Research Fields 研究领域

NOTCH signaling
breast cancer
cancer stem cells
tumor microenvironment
therapeutic targeting

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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