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Translational Medicine / 转化医学Immunosuppression, Tumor-Infiltrating Tregs

Bharat Bhatt

MD, PhD

🏢Yale School of Medicine🌐USA

Professor of Cancer Immunology

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👥Biography 个人简介

Bharat Bhatt investigates tumor-infiltrating regulatory T cells and how they create an immunosuppressive niche that limits antitumor immunity. His research has characterized the phenotypic and functional heterogeneity of tumor Tregs across different cancer types. He has studied mechanisms by which CTLA-4 antibodies deplete tumor-infiltrating Tregs via Fc receptor-dependent killing. His work has informed strategies for selective Treg depletion in tumors while preserving peripheral immune tolerance.

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🧪Research Fields 研究领域

tumor-infiltrating Tregs
Treg depletion strategies
anti-CTLA-4 Treg mechanism
CCR4 Treg targeting
Treg immune suppression tumors

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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