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Translational Medicine / 转化医学Angiogenesis & Anti-VEGF

Beverly A. Teicher

贝弗利·泰谢尔

PhD

🏢National Cancer Institute (NCI)(美国国家癌症研究所)🌐USA

Senior Investigator, Developmental Therapeutics Branch发育治疗学部高级研究员

72
h-index
2
Key Papers
3
Awards
2
Key Contributions

👥Biography 个人简介

Beverly Teicher is a leading authority on tumor microvasculature and antiangiogenic combination therapy at the NCI. Her laboratory established key preclinical frameworks for combining antiangiogenic agents with chemotherapy and radiation, demonstrating how microvessel density affects tumor drug resistance and treatment response.

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🧪Research Fields 研究领域

Tumor Microvasculature肿瘤微血管系统
Antiangiogenic Combination Therapy抗血管生成联合治疗
Hypoxia and Drug Resistance缺氧与耐药
Squalamine角鲨胺
Preclinical Tumor Models临床前肿瘤模型

🎓Key Contributions 主要贡献

Antiangiogenic Combination Strategies

Demonstrated that antiangiogenic agents combined with conventional chemotherapy overcome hypoxia-mediated drug resistance, establishing preclinical models still used in translational oncology.

Tumor Microvasculature and Drug Delivery

Characterized how abnormal tumor microvasculature creates hypoxic gradients that limit chemotherapy penetration, informing vessel-targeting combination strategies.

Representative Works 代表性著作

[1]

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis

Journal of the National Cancer Institute Monographs (2001)

Comprehensive analysis of how antiangiogenic interventions influence not only tumor growth but also invasion and metastatic dissemination.

[2]

Tumor vascularity: a histological measure of angiogenesis and hypoxia

Cancer Research (1994)

Established quantitative histological methods for assessing tumor microvessel density that became standard tools in antiangiogenic drug evaluation.

🏆Awards & Recognition 奖项与荣誉

🏆NCI Merit Award
🏆American Association for Cancer Research Fellow
🏆Society of Toxicology Distinguished Scientist Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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