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Translational Medicine / 转化医学Innate Immunity, Nobel Laureate 2011

Bruce Beutler

MD

🏢UT Southwestern Medical Center🌐USA

Director, Center for the Genetics of Host Defense

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Key Contributions

👥Biography 个人简介

Bruce Beutler shared the 2011 Nobel Prize in Physiology or Medicine for discoveries concerning the activation of innate immunity, specifically identifying TLR4 as the receptor for lipopolysaccharide. His work established Toll-like receptors as key pattern recognition receptors. These discoveries shaped vaccine adjuvant and cancer innate immunity strategies.

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🧪Research Fields 研究领域

Toll-like receptors
innate immunity
LPS sensing
TLR4
Nobel Prize

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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