Bert Vogelstein

Bert Vogelstein is the Clayton Professor of Oncology at Johns Hopkins and an HHMI Investigator. He is the most-cited biomedical scientist in history, with over 300,000 total citations. His foundational discoveries have shaped modern oncology more than perhaps any other living scientist. Vogelstein's laboratory discovered or co-discovered: the multistep genetic model of colorectal cancer (showing cancer requires sequential accumulation of driver mutations), the role of APC in colon cancer initiation, that p53 is the most commonly mutated gene in human cancer, and the concept of driver vs. passenger mutations. More recently, his laboratory has pioneered cancer early detection using liquid biopsy approaches including the CancerSEEK multi-analyte blood test and ctDNA-based minimal residual disease testing. He has cofounded multiple companies including Personal Genome Diagnostics.

Bert Vogelstein 是约翰·霍普金斯大学的克莱顿肿瘤学教授，也是HHMI研究员。他是历史上被引用次数最多的生物医学科学家，总引用次数超过300,000次。他的奠基性发现比任何其他在世科学家更深刻地塑造了现代肿瘤学。 Vogelstein的实验室发现或共同发现了：结直肠癌的多步骤遗传模型（表明癌症需要驱动突变的序列积累）、APC在结肠癌启动中的作用、p53是人类癌症中最常见的突变基因，以及驱动突变与乘客突变的概念。