Bert Vogelstein
伯特·福格尔斯坦
MD
Clayton Professor of Oncology; Co-Director, Ludwig Center for Cancer Genetics and TherapeuticsClayton肿瘤学讲席教授；路德维希癌症遗传与治疗中心联合主任
👥Biography 个人简介
One of the most cited scientists in history and the defining figure in colorectal cancer genetics. His multistep model of colorectal carcinogenesis, APC/KRAS/TP53 pathway discoveries, and liquid biopsy innovations have transformed understanding of hereditary and sporadic cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Multistep Colorectal Cancer Model
Elucidated the genetic steps of colorectal cancer development through APC, KRAS, SMAD4, and TP53 mutations, establishing the canonical model of tumor suppressor/oncogene cooperation that underpins hereditary CRC surveillance rationale.
TP53 and Hereditary Cancer
Characterized TP53 as the most frequently mutated gene in human cancer and defined its role in Li-Fraumeni syndrome, directly informing hereditary cancer genetic testing panels and surveillance protocols.
Representative Works 代表性著作
Genetic alterations during colorectal tumor development
New England Journal of Medicine (1988)
Seminal paper describing stepwise accumulation of somatic mutations driving colorectal carcinogenesis, establishing the paradigm for hereditary and sporadic CRC genetics.
Cancer genome landscapes
Science (2013)
Comprehensive analysis of somatic mutation landscapes across human cancers, revealing driver gene frequencies and mutational signatures across tumor types.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 伯特·福格尔斯坦 的研究动态
Follow Bert Vogelstein's research updates
留下邮箱，当我们发布与 Bert Vogelstein（Johns Hopkins University School of Medicine）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment