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Translational Medicine / 转化医学TGF-beta, SMAD Signaling, Cancer

Bert Bhatt

PhD

🏢Harvard Medical School🌐USA

Cell Biologist

18
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Key Papers
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Key Contributions

👥Biography 个人简介

Bert Bhatt studies TGF-beta/SMAD signaling in cancer — a pathway that acts as a tumor suppressor in early-stage cancers (inhibiting proliferation) but promotes invasion, metastasis, and immune evasion in advanced cancers. This duality of TGF-beta in cancer biology complicates therapeutic targeting. Research on the molecular determinants of the tumor suppressive versus pro-metastatic TGF-beta switch, and on SMAD4 loss in pancreatic and colorectal cancer, informs cancer biology and treatment strategy.

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🧪Research Fields 研究领域

TGF-beta tumor suppressor oncogene
SMAD signaling cancer
TGF-beta duality cancer
TGF-beta invasion metastasis
SMAD4 pancreatic cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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