Bernhard Kuster

Bernhard Kuster is a leader in chemoproteomics and drug target discovery, developing chemical proteomics approaches that reveal the complete target landscape of kinase inhibitors and other cancer drugs. His laboratory has comprehensively profiled the selectivity of cancer therapeutics using mass spectrometry, revealing unexpected targets and off-target effects that explain both efficacy and toxicity. He has also developed cancer cell line proteomes as resources for the research community. His work connects proteomics with cancer pharmacology and enables more rational drug development.