Benjamin J. Solomon
本杰明·所罗门
MBBS, PhD, FRACP
Medical Oncologist; Associate Professor of Medicine肿瘤内科医生；医学副教授
👥Biography 个人简介
Australia's leading expert in ALK and EGFR-targeted therapies in NSCLC. Principal investigator for the CROWN trial establishing lorlatinib as the gold standard for ALK-positive NSCLC, and co-investigator in numerous EGFR TKI global trials from Peter MacCallum Cancer Centre.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CROWN Trial - Lorlatinib
Led the CROWN phase III trial demonstrating lorlatinib's superior PFS over crizotinib in ALK-positive NSCLC with unprecedented intracranial activity, establishing lorlatinib as preferred first-line ALK TKI.
EGFR Resistance and Brain Metastases
Contributed landmark data on CNS activity of EGFR and ALK inhibitors in NSCLC brain metastases, influencing guidelines on CNS prophylaxis and TKI selection for patients with brain involvement.
Representative Works 代表性著作
Lorlatinib versus Crizotinib in First-Line Treatment of Advanced ALK-Positive NSCLC (CROWN)
New England Journal of Medicine (2020)
Definitive phase III trial showing lorlatinib superiority, with 3-year PFS of 64% and exceptional CNS activity, setting new standard for ALK-positive NSCLC.
Lorlatinib in Patients with ALK-Positive Non–Small-Cell Lung Cancer: Results from a Global Phase 2 Study
Lancet Oncology (2018)
Pivotal phase II data demonstrating lorlatinib activity in heavily pretreated ALK-positive and EGFR-mutant NSCLC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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