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Translational Medicine / 转化医学Epigenetic MHC Silencing, Single-Cell Immunology

Benjamin Izar

MD, PhD

🏢Columbia University Irving Medical Center🌐USA

Assistant Professor of Medicine

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👥Biography 个人简介

Benjamin Izar has applied single-cell multi-omics approaches to reveal epigenetic mechanisms of MHC silencing in immunotherapy-resistant cancers. His work demonstrated that EZH2-mediated histone methylation represses MHC-I genes in melanoma, establishing epigenetic drugs as a strategy to restore antigen presentation. He has generated comprehensive single-cell atlases of the tumor immune microenvironment that define the landscape of immune evasion programs.

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🧪Research Fields 研究领域

epigenetic MHC silencing
single-cell tumor immunology
melanoma immune resistance
EZH2 MHC repression
chromatin remodeling immune evasion

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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