Benjamin Ebert
本杰明·埃伯特
MD, PhD
Chair, Department of Medical Oncology; George P. Canellos MD Professor of Medicine肿瘤内科系主任；乔治·卡内洛斯医学教授
👥Biography 个人简介
Benjamin Ebert is a world leader in clonal hematopoiesis and the epigenetic basis of myeloid malignancies. His research has defined the mutational landscape of MDS and AML, elucidated how TET2, DNMT3A, and splicing factor mutations drive clonal expansion and malignant transformation, and identified novel therapeutic strategies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Clonal Hematopoiesis Biology and Risk
Performed landmark studies defining the prevalence, mutational drivers, and cardiovascular and malignancy risks of clonal hematopoiesis of indeterminate potential (CHIP), establishing it as a major aging-related risk factor.
TET2 and DNMT3A in Myeloid Transformation
Characterized how TET2 loss and DNMT3A mutations alter hematopoietic stem cell self-renewal programs through aberrant DNA methylation and hydroxymethylation, promoting clonal dominance and MDS/AML evolution.
Splicing Factor Mutations in MDS
Defined recurrent somatic mutations in splicing factors (SF3B1, SRSF2, U2AF1) as key epigenetic-adjacent drivers of MDS, explaining how dysregulated splicing disrupts chromatin regulatory gene networks.
Representative Works 代表性著作
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
New England Journal of Medicine (2017)
Demonstrated that CHIP mutations in TET2 and DNMT3A increase cardiovascular disease risk through epigenetic dysregulation of inflammatory macrophages.
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
Nature (2015)
Revealed mechanism of lenalidomide in MDS, showing it acts as a molecular glue degrader targeting CK1α via CRBN E3 ligase.
Somatic mutations in hematopoietic stem and progenitor cells and their role in the development of cancer
Cell Stem Cell (2019)
Comprehensive review of somatic mutation accumulation in HSCs and how epigenetic drivers initiate clonal hematopoiesis and malignancy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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