David Basanta

David Basanta applies evolutionary game theory to model strategic interactions between cancer cell phenotypes and between tumor and stromal cells, demonstrating that tumor evolution can be understood as a series of evolutionary games whose outcomes depend on the frequency and spatial distribution of competing strategies. His research at Moffitt Cancer Center has modeled bone metastasis establishment as an evolutionary game between osteoblasts, osteoclasts, and cancer cells, identifying therapeutic interventions that can shift game payoffs to favor tumor control. His work provides the game-theoretic foundation for designing evolutionary therapy strategies.