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Translational Medicine / 转化医学Epigenetic Clock and Biological Aging

Nir Barzilai

MD

🏢Albert Einstein College of Medicine🌐USA

Professor of Medicine and Director of Institute for Aging Research

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Key Contributions

👥Biography 个人简介

Nir Barzilai leads the TAME (Targeting Aging with Metformin) trial, the first FDA-approved clinical trial targeting aging as a disease indication, with cancer incidence as a primary endpoint and epigenetic clocks as key secondary biomarkers. His studies of centenarian genetics have identified protective variants that reduce both aging rate and cancer susceptibility. He is a leader in the geroscience movement that positions aging as the primary modifiable risk factor for cancer.

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🧪Research Fields 研究领域

Centenarian genetics
TAME trial metformin
Longevity genes and cancer
Insulin-IGF-1 axis aging
Geroscience and cancer prevention

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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