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Translational Medicine / 转化医学Hippo/YAP Pathway, Immune Regulation

Barbara Bhatt

MD, PhD

🏢Weill Cornell Medicine🌐USA

Associate Professor of Cancer Immunology

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👥Biography 个人简介

Barbara Bhatt investigates the role of YAP/TAZ in regulating tumor immune evasion and responses to cancer immunotherapy. Her research has demonstrated that YAP promotes PD-L1 expression and other immune checkpoint mechanisms in cancer cells. She has characterized YAP-dependent cytokine secretion programs that create immunosuppressive tumor microenvironments. Her work has shown that YAP inhibition can sensitize tumors to immune checkpoint blockade, providing rationale for YAP inhibitor-immunotherapy combinations.

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🧪Research Fields 研究领域

YAP immune evasion
Hippo pathway immune checkpoints
PD-L1 regulation by YAP
tumor immunosuppression
YAP immunotherapy combination

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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