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Translational Medicine / 转化医学Infection-Associated Cancer in Tropical/LMICs

Charles Bangham

MA, BM BCh, DPhil

🏢Imperial College London🌐UK

Professor of Immunology and Co-Director, Institute of Infection

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👥Biography 个人简介

Charles Bangham is a world authority on HTLV-1, the retrovirus that causes adult T-cell leukemia/lymphoma predominantly in tropical endemic regions including Japan, the Caribbean, and sub-Saharan Africa. His research has elucidated how HTLV-1 drives clonal expansion of infected T-cells through the Tax and HBZ oncoproteins, eventually leading to malignant transformation. His quantitative virology approach has provided critical insights into why only a fraction of HTLV-1 carriers develop cancer, informing risk stratification in endemic populations.

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🧪Research Fields 研究领域

HTLV-1 adult T-cell leukemia
Retroviral oncogenesis
T-cell clonality HTLV-1
Tropical spastic paraparesis
Viral persistence and cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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