Gianluca Baldanzi

Gianluca Baldanzi elucidated the metabolic regulation of ILC effector functions, demonstrating that diacylglycerol kinase signaling controls the balance between ILC activation and exhaustion in the tumor microenvironment through modulation of mTOR and MAPK pathways. His work on lipid signaling in innate lymphocytes revealed that tumor-derived lipid mediators reprogram ILC metabolism toward a pro-tumorigenic phenotype. He investigates metabolic intervention strategies to restore anti-tumor ILC functions in lipid-rich tumor microenvironments.