Ayalew Tefferi

Ayalew Tefferi is a preeminent hematologist at Mayo Clinic whose extensive body of work has defined the natural history, prognosis, and treatment of the full spectrum of MPNs. He contributed to the characterization of calreticulin (CALR) mutations as the second most common driver in MPL-negative polycythemia vera and myelofibrosis, clarifying their distinct prognostic implications. His large-scale registry analyses have established survival benchmarks and prognostic scoring systems widely used in MPN clinical decision-making. He is a prolific author and educator in myeloid malignancies.