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Translational Medicine / 转化医学Lung Cancer, KRAS G12C

Mark Awad

MD, PhD

🏢Brigham and Women's Hospital / Dana-Farber Cancer Institute🌐USA

Clinical Director of Thoracic Oncology

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👥Biography 个人简介

Dr. Mark Awad is a leading thoracic oncologist specializing in molecularly targeted therapies for NSCLC. He has led the KRYSTAL-1 trial evaluating adagrasib in KRAS G12C-mutant lung cancer and contributed fundamental insights into co-mutation landscapes that modulate KRAS inhibitor response. His laboratory investigates acquired resistance mechanisms to KRAS G12C inhibitors including secondary KRAS mutations.

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🧪Research Fields 研究领域

KRAS G12C lung cancer
adagrasib KRYSTAL-1
targeted therapy resistance
co-mutations KRAS
STK11 KEAP1 co-mutations

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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