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Cell Therapy / 细胞治疗CAR-T

Avery D. Posey Jr.

Ph.D.

🏢University of Pennsylvania🌐USA

Assistant Professor, Department of Systems Pharmacology

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Key Papers
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Key Contributions

👥Biography 个人简介

Avery Posey is an emerging leader in CAR-T cell engineering with particular focus on targeting solid tumors. His laboratory develops novel CAR designs targeting tumor-associated carbohydrates (glycans) and other solid tumor antigens. Posey's work on glycan-targeting CARs has opened new approaches for cancers that have been refractory to conventional CAR-T therapy.

Avery Posey是CAR-T细胞工程领域的新兴领导者,特别关注靶向实体肿瘤。他的实验室开发靶向肿瘤相关碳水化合物(聚糖)和其他实体肿瘤抗原的新型CAR设计。Posey在聚糖靶向CAR方面的工作为对常规CAR-T治疗耐药的癌症开辟了新方法。

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🧪Research Fields 研究领域

CAR-T EngineeringCAR-T工程
Glycoengineering糖工程
Solid Tumor Immunotherapy实体肿瘤免疫治疗

🎓Key Contributions 主要贡献

Glycan-Targeting CARs

Developed CARs targeting tumor-specific glycan modifications.

Solid Tumor CAR-T

Engineering approaches to overcome solid tumor microenvironment barriers.

Representative Works 代表性著作

[1]

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Immunity (2016)

First demonstration of glycan-targeting CAR-T cells.

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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