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Translational Medicine / 转化医学MSI-H/dMMR Tumor-Agnostic IO

Aurelien Marabelle

MD, PhD

🏢Gustave Roussy🌐France

Clinical Director of Cancer Immunotherapy Program

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Key Contributions

👥Biography 个人简介

Aurelien Marabelle co-led KEYNOTE-158 and related pembrolizumab MSI-H basket studies that supported the first tumor-agnostic checkpoint inhibitor approval, establishing microsatellite instability-high and mismatch repair deficiency as pan-tumor predictive biomarkers. He also contributed to dostarlimab dMMR development. His work shaped tumor-agnostic IO biomarker strategy globally.

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🧪Research Fields 研究领域

pembrolizumab MSI-H tumor-agnostic
dostarlimab dMMR pan-tumor
KEYNOTE-158
MSI/dMMR prevalence
tumor-agnostic IO biomarkers

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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