Arlene Sharpe
MD, PhD
Chair, Department of Immunology
👥Biography 个人简介
Arlene Sharpe is a founding figure in the biology of PD-1 and co-inhibitory receptors governing T cell exhaustion. Her laboratory has mapped the epigenetic landscape of exhausted T cells, revealing stable chromatin changes that limit reinvigoration by checkpoint blockade. She demonstrated how TOX and NR4A transcription factors drive epigenetic programming of exhaustion. Her translational work has direct implications for overcoming IO resistance in cancer patients.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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