Antonis Antoniou

Antonis Antoniou at the University of Cambridge is a leading biostatistician who developed the BOADICEA cancer risk prediction model and has quantified cancer risks associated with moderate-penetrance genes including PALB2. His analyses established PALB2 as a high-risk breast cancer gene with risk approaching BRCA2, fundamentally changing clinical management guidelines for PALB2 carriers. His models integrate gene effects with polygenic risk scores.