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Translational Medicine / 转化医学Mantle Cell Lymphoma, Pirtobrutinib

Anthony Mato

MD, MSCE

🏢Memorial Sloan Kettering Cancer Center🌐USA

Director, CLL Program

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👥Biography 个人简介

Anthony Mato led early-phase investigation of pirtobrutinib, the first non-covalent (reversible) BTK inhibitor, in patients with MCL and CLL who had progressed on prior covalent BTK inhibitor therapy. His work on the BRUIN trial demonstrated impressive response rates in post-ibrutinib MCL patients. He is internationally recognized for expertise in BTK inhibitor sequencing and resistance mechanisms.

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🧪Research Fields 研究领域

pirtobrutinib
non-covalent BTK inhibitor
BTK resistance MCL
CLL MCL
BRUIN trial

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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