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Translational Medicine / 转化医学endocrine oncology

Anna Pia

安娜·皮亚

MD, PhD

🏢University of Turin, A.O.U. Città della Salute e della Scienza(都灵大学,都灵健康与科学城市医院)🌐Italy

Associate Professor of Endocrinology; Head, Calcium and Bone Metabolism Unit内分泌学副教授;钙与骨代谢科主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Anna Pia, MD, PhD is Associate Professor of Endocrinology at the University of Turin and head of the Calcium and Bone Metabolism Unit, with expertise in parathyroid carcinoma, CDC73/HRPT2 tumor suppressor genetics, and endocrine disruptor-related cancer risk. She has led European multicenter studies characterizing the clinical presentation, molecular basis, and treatment outcomes of parathyroid carcinoma—one of the rarest endocrine malignancies—and contributed to understanding how environmental endocrine-disrupting compounds influence parathyroid and thyroid tumorigenesis. Her work has informed European guidelines for parathyroid carcinoma management.

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🧪Research Fields 研究领域

Parathyroid Carcinoma甲状旁腺癌
Primary Hyperparathyroidism原发性甲状旁腺功能亢进
CDC73 MutationsCDC73基因突变
Endocrine Disruption内分泌干扰
Calcium Metabolism Disorders钙代谢紊乱

🎓Key Contributions 主要贡献

CDC73 Tumor Suppressor in Parathyroid Carcinoma

Characterized CDC73/parafibromin loss as a key diagnostic and prognostic marker in parathyroid carcinoma, establishing immunohistochemical parafibromin staining as a standard adjunct in differentiating malignant from adenomatous parathyroid lesions.

European Registry for Parathyroid Carcinoma

Helped establish and analyze the European multicenter parathyroid carcinoma registry, providing the largest clinical dataset characterizing presentation, surgical outcomes, recurrence patterns, and systemic therapy responses in this rare malignancy.

Endocrine Disruptors and Thyroid/Parathyroid Cancer Risk

Investigated associations between environmental endocrine-disrupting chemicals (EDCs) and the development of thyroid nodules, differentiated thyroid cancer, and parathyroid adenoma, contributing epidemiological and mechanistic evidence to the EDC-cancer risk literature.

Representative Works 代表性著作

[1]

Parathyroid Carcinoma: Presentation, Management, and Outcomes in a European Multicenter Cohort

Journal of Clinical Endocrinology & Metabolism (2020)

Multicenter European analysis defining contemporary clinical features, surgical cure rates, and long-term outcomes in parathyroid carcinoma.

[2]

CDC73 Mutations and Parafibromin Expression as Diagnostic Markers of Parathyroid Malignancy

Endocrine-Related Cancer (2018)

Validated parafibromin immunostaining and CDC73 sequencing as complementary tools for diagnosing parathyroid carcinoma in challenging cases.

🏆Awards & Recognition 奖项与荣誉

🏆European Society of Endocrinology Young Investigator Award 2016
🏆Italian Society of Endocrinology Research Merit Award 2020
🏆European Network for Rare Endocrine Tumors (ENETS) Clinical Research Grant 2022

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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