Warren Chan

Warren Chan is a Professor at the University of Toronto's Institute of Biomedical Engineering and Canada Research Chair in Nanotechnology and Regenerative Medicine. He is a world leader in understanding how nanoparticles navigate biological systems and reach tumors. Chan's landmark meta-analysis of the nanomedicine literature (2016) revealed that, on average, only 0.7% of administered nanoparticles reach their tumor target — a sobering finding that ignited global debate about the EPR (Enhanced Permeability and Retention) effect and the fundamental challenges of nanoparticle delivery. His laboratory systematically investigates how nanoparticle size, shape, surface chemistry, and dose affect their journey through the body, providing design rules to improve delivery efficiency. His work has identified that nanoparticles accumulate in tumors primarily via active transport through tumor blood vessel cells, not passive EPR.

Warren Chan 是多伦多大学生物医学工程研究所教授，也是加拿大纳米技术与再生医学首席研究员。他是理解纳米颗粒如何在生物系统中导航并到达肿瘤领域的世界领军人物。 Chan 对纳米医学文献的里程碑式元分析（2016年）揭示，平均只有0.7%的给药纳米颗粒能够到达肿瘤目标——这一令人警醒的发现引发了全球关于EPR（增强渗透性和保留）效应以及纳米颗粒递送根本挑战的辩论。