Andrew Gewirtz

Andrew Gewirtz investigates how gut microbiome composition and host innate immune sensing interact to influence colorectal cancer development. His laboratory has demonstrated that disruption of microbiome homeostasis and altered TLR signaling promotes intestinal inflammation and carcinogenesis. He characterized how specific microbiome dysbiosis patterns associate with colorectal cancer risk and how microbial metabolites modulate intestinal epithelial proliferation and tumor development. His work provides mechanistic insights into microbiome contributions to colorectal carcinogenesis with potential implications for cancer prevention.