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Translational Medicine / 转化医学Cancer Evolution, Mathematical Modeling

Andrea Sottoriva

PhD

🏢UCL Cancer Institute / Human Technopole Milan🌐UK

Professor of Computational Cancer Genomics

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👥Biography 个人简介

Andrea Sottoriva proposed the Big Bang model of colorectal tumor growth, demonstrating that intratumor heterogeneity is established early and maintained through neutral evolution without stringent clonal selection. His mathematical frameworks for inferring evolutionary dynamics from genomic data have transformed understanding of how tumors evolve and diversify. He has established quantitative methods linking tumor evolution patterns to clinical outcomes.

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🧪Research Fields 研究领域

cancer evolution mathematical
Big Bang model
neutral evolution cancer
intratumor heterogeneity
clonal dynamics modeling

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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