Andrea Bhatt

Andrea Bhatt investigates how the gut microbiome modulates cancer drug metabolism and combination therapy efficacy, revealing that bacterial enzyme activities can activate or inactivate anti-cancer drugs and that antibiotic co-administration can alter chemotherapy pharmacokinetics and toxicity profiles in ways that affect combination therapy outcomes. Her research at Stanford has demonstrated that microbiome composition is an underappreciated variable in drug combination synergy and that incorporating microbiome data improves prediction of patient-specific combination therapy responses. Her work is opening a new dimension in combination therapy optimization by integrating microbiome pharmacology.