Ana O. Hoff
安娜·奥·霍夫
MD, PhD
Associate Professor; Head, Endocrine Oncology Section副教授；内分泌肿瘤科主任
👥Biography 个人简介
Ana O. Hoff, MD, PhD is a leading endocrine oncologist at ICESP, University of São Paulo, recognized for her research on medullary thyroid cancer genetics, MEN2 kindreds in Brazilian populations, and hereditary endocrine tumor syndromes. She has characterized regional RET mutation spectra in Latin America, discovering novel pathogenic variants and adapting international surveillance guidelines to local genetic epidemiology. Her clinical program integrates molecular genetic testing with risk-stratified prophylactic interventions and has trained a generation of endocrine oncologists in Brazil and across Latin America.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
RET Mutation Landscape in Brazilian MEN2 Kindreds
Characterized the spectrum of RET germline mutations in the largest Brazilian MEN2 registry, identifying population-specific variants and adapting risk-stratification guidelines for Latin American patients.
Prophylactic Thyroidectomy Protocols for MEN2 Carriers
Developed institutional protocols for risk-stratified prophylactic thyroidectomy in pediatric and adult MEN2 mutation carriers, demonstrating excellent long-term outcomes and contributing to Brazilian national guidelines.
Calcitonin Kinetics as Prognostic Biomarker in MTC
Defined calcitonin doubling time thresholds and their prognostic significance in MTC surveillance, providing practical tools for post-treatment monitoring and early detection of disease progression.
Representative Works 代表性著作
RET Proto-oncogene Mutations and Clinical Features of MEN2 in Brazil
Clinical Endocrinology (2018)
Comprehensive genetic epidemiology study defining RET mutation distribution in a large Brazilian MEN2 cohort and reporting genotype-phenotype correlations.
Calcitonin Doubling Time as a Prognostic Tool in Medullary Thyroid Carcinoma
Journal of Clinical Endocrinology & Metabolism (2021)
Validated calcitonin doubling time as an independent predictor of disease-specific survival in MTC patients after initial surgery.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Ana O. Hoff（Instituto do Câncer do Estado de São Paulo (ICESP), University of São Paulo）相关的新研究或访谈时，我们会通知你。
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