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Translational Medicine / 转化医学Hematologic Malignancy Milestones

Frederick Alt

PhD

🏢Harvard Medical School / Boston Children's Hospital🌐USA

Charles A. Janeway Professor of Pediatrics and Genetics

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Key Contributions

👥Biography 个人简介

Frederick Alt is a preeminent molecular immunologist who elucidated the V(D)J recombination mechanism generating antibody diversity and discovered how errors in this process lead to B-cell lymphomas. His work on chromosomal translocation mechanisms has been fundamental to understanding lymphomagenesis. His contributions bridge basic immunology with hematologic malignancy biology.

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🧪Research Fields 研究领域

V(D)J recombination
Immunoglobulin gene rearrangement
B-cell lymphoma genomics
DNA repair mechanisms
Chromosomal translocation biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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