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Translational Medicine / 转化医学TCR, CD28, and Checkpoint Biology

James Allison

PhD

🏢MD Anderson Cancer Center🌐USA

Professor and Chair, Immunology

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Key Contributions

👥Biography 个人简介

James Allison performed foundational work on the T cell receptor complex and CD28 costimulation, and subsequently discovered that CTLA-4 blockade could unleash antitumor immunity. His Nobel Prize winning work launched the modern era of cancer immunotherapy. He continues to lead translational programs in combination checkpoint therapy.

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🧪Research Fields 研究领域

TCR biology
CD28 costimulation
CTLA-4
checkpoint blockade
tumor immunology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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