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Translational Medicine / 转化医学ctDNA Real-Time Therapy Monitoring

Ash Alizadeh

MD, PhD

🏢Stanford University🌐USA

Professor of Medicine and Genetics

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👥Biography 个人简介

Ash Alizadeh co-invented the CAPP-Seq technology for ultrasensitive ctDNA detection and has led its clinical application for monitoring treatment response in lymphoma and lung cancer, establishing ctDNA-based molecular response definitions that predict patient outcomes independently of imaging assessments. His research at Stanford has demonstrated that ctDNA dynamics during the first cycles of therapy can identify patients likely to achieve durable remissions versus those requiring treatment intensification. His work has been instrumental in defining ctDNA as a quantitative biomarker for real-time therapy monitoring across multiple cancer types.

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🧪Research Fields 研究领域

CAPP-Seq ctDNA technology
Lymphoma ctDNA monitoring
Molecular response definition
ctDNA minimal residual disease
Duplex sequencing error correction

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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