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Translational Medicine / 转化医学NSCLC, ALK-Targeted Therapy

Alice T. Shaw

MD, PhD

🏢Novartis Oncology / Massachusetts General Hospital🌐USA

Chief Medical Officer; Former Associate Professor of Medicine

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👥Biography 个人简介

Alice Shaw is a world-leading authority on ALK-rearranged NSCLC who led foundational studies establishing crizotinib and alectinib as transformative therapies for this molecularly defined lung cancer subtype. Her laboratory and clinical research defined mechanisms of resistance to first- and second-generation ALK inhibitors and informed the development of third-generation inhibitors. She now serves as Chief Medical Officer at Novartis Oncology, translating discoveries from bench to global clinical practice. Her contributions have been recognized with numerous national and international awards.

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🧪Research Fields 研究领域

ALK-positive NSCLC
crizotinib
alectinib
ALK resistance
next-generation ALK inhibitors

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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