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Translational Medicine / 转化医学H3K4 Methylation, COMPASS Complex

Ali Shilatifard

PhD

🏢Northwestern University Feinberg School of Medicine🌐USA

Robert Francis Furchgott Professor

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Key Contributions

👥Biography 个人简介

Ali Shilatifard at Northwestern has made major contributions to understanding histone H3K4 methylation through the COMPASS family of complexes, including how MLL fusion proteins dysregulate H3K4 and H3K79 methylation patterns to drive acute leukemia. His work on super-enhancers in cancer and on the mechanistic basis for DOT1L inhibitor activity in MLL-rearranged leukemias has contributed to both basic chromatin biology and cancer therapy development.

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🧪Research Fields 研究领域

COMPASS H3K4 methylation
MLL leukemia chromatin
H3K4me3 active gene regulation
super-enhancers cancer
DOT1L H3K79 methylation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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